منابع مشابه
Are denatured proteins ever random coils?
T polymer chemists, the term random coil means a chain molecule whose backbone coils randomly in three-dimensional space, with a conformation described by the Gaussian probability function (1). To protein chemists, the term random coil carries an added special meaning: the backbone conformation of every amino acid residue, described by its phi, psi pair of backbone angles, is independent of the...
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Language users never choose words randomly, and language is essentially non-random. Statistical hypothesis testing uses a null hypothesis, which posits randomness. Hence, when we look at linguistic phenomena in corpora, the null hypothesis will never be true. Moreover, where there is enough data, we shall (almost) always be able to establish that it is not true. In corpus studies, we frequently...
متن کاملScaling behavior and structure of denatured proteins.
An ensemble of random-coil conformations with no persistent structures has long been accepted as the classical model of denatured proteins due to its consistency with the experimentally determined scaling of protein sizes. However, recent NMR spectroscopy studies on proteins at high chemical denaturant concentrations suggest the presence of significant amounts of native-like structures, in cont...
متن کاملHeat capacity and compactness of denatured proteins.
One of the striking results of protein thermodynamics is that the heat capacity change upon denaturation is large and positive. This change is generally ascribed to the exposure of non-polar groups to water on denaturation, in analogy to the large heat capacity change for the transfer of small non-polar molecules from hydrocarbons to water. Calculations of the heat capacity based on the exposed...
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The aging population increases the demand of intensive care unit (ICU) treatments. However, the availability of ICU beds is limited. Thus, ICU admission of octogenarians is considered controversial. The population above 80 years is a very heterogeneous group though, and age alone might not be the best predictor. Aim of this study was to analyze resource consumption and outcome of octogenarians ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.97.23.12391